Light-Activated Therapy and Aging Skin

A study in the October issue of the Archives of Dermatology, supports that Photodynamic therapy appears to cause molecular-level changes in aging skin that increase collagen production and improve skin appearance, a U.S. study finds. Meaning, light-activated therapy seems to rejuvenate aging skin.

In photodynamic therapy, a light-activated medication is exposed to a light source. Photodynamic therapy for aesthetic treatments typically involves application of a topical medication, such as 5-aminolevulinic acid (5-ALA).

In this study, Dr. Jeffrey S. Orringer and colleagues at the University of Michigan Medical School in Ann Arbor, used photodynamic therapy to treat 25 people, aged 54 to 83, with sun-damaged skin on their forearms.

Prior to treatment, the patients’ degree of skin damage was rated, and tissue samples were taken from their forearms. A solution containing 5-ALA was applied to the damaged skin and left on for three hours. The skin was then cleaned and treated with a pulsed-dye laser. The patients were re-examined four to five times over the following six months.

Tissue samples showed that treatment resulted in a fivefold increase in levels of a protein called Ki67, believed to play an important role in the growth and development of new skin cells. In addition, there was a 1.4-fold increase in the thickness of the skin’s outer layer (epidermis) and higher levels of enzymes and other compounds associated with the production of collagen, the main structural protein in skin.

“Photodynamic therapy with the specific treatment regimen employed produces statistically significant quantitative cutaneous molecular changes [e.g., production of types I and III collagen] that are associated with improved appearance of the skin,” the researchers wrote.

The findings suggest that use of a photosensitive compound such as 5-ALA in combination with pulsed-dye laser therapy prompts more beneficial changes in skin than laser therapy alone.

“Although our molecular measurements cannot yet precisely predict clinical outcomes for a single given patient, taken together they are very much in keeping with the bulk of the clinical literature and thus lend substantial support to the conclusions reached by other researchers who have published purely clinically oriented work in this field,” the study authors concluded.

“We believe that the quantitative amount of dermal repair and regeneration induced by a specific therapeutic intervention very likely underlies the degree of clinical rejuvenation produced.” they wrote. “Thus, it is our hope that, with further development, our working molecular model may one day be used to predict the clinical value of new technologies in aesthetic dermatology.”

Everyday skincare for dry, wrinkled or sun-damaged skin

Many of us, women especially, can relate to the phrase, “I just don’t have the time.” Conversely, if you grew up in any generation or location that frowned upon wearing makeup or using ‘beauty products’ as ‘unnatural’, you might have recently had second thoughts as those lines began to show a little too much, or those dark spots were just getting darker.

You have lived long enough to know “beauty isn’t everything,” but the truth is, when it starts to fade, boy, does it sure seem more important!

Regardless of the circumstance that finally brought you to shock the last time you looked in the mirror, the good news is; there are always second chances when it comes to taking care of your skin. The older you are, the more important it is to get started with a quality skin care regimen.

Three simple steps can aid your skin back the face you knew yesterday. You might have heard this before, but here it is again…just in case you need a refresher.

1. Cleanse - but gently. Too many professional skin care products strip your facial skin of the natural elements it needs to keep your skin soft and supple. Using a mild cleanser with a very light, delicate scent that won’t leave your face feeling tight and dry. For damaged, wrinkled skin, a moisturizing cleanser or cream cleanser is best.

2. Exfoliate - Many exfoliating products using sand or walnut shells can be too harsh to use daily - try to find a gentle exfoliating product – a natural clay or organic oatmeal. Natural skin care products tend to be less irritating and will not only exfoliate the grime and pollution of the day from your delicate facial skin, they also moisturize, soften, and increase your body’s collagen and antioxidant production.

3. Moisturize - Use a dry skin care anti aging lotion each morning after cleansing. Excellent high quality moisturizers not only replace vital moisture in your face but leave it soft and smooth. Additional moisture will also supplement the antioxidants your skin needs to produce to stay looking healthy and young. If you use an SPF of in your moisturizer or foundation, it will also help protect your face from sun damage throughout the day.

One more thing…

The goal of your skin care routine is to address wrinkles, dark spots and dryness with products that deliver lighting, moisturizing and anti-wrinkle ingredients.
It’s not enough to get a facial to keep your skin clear and beautiful. You need to have a great home skin-care routine. I never hurts, to get a professional facial to deep cleanse your skin at least four times a year, as the seasons change. Every 4-6 weeks is ideal. But please, throw away the grocery-store soap and use quality skin care products that are right for your skin type. Also, if it still has to be said, wear sunscreen, even on cloudy days and in the winter. Use a good quality, high-SPF sunscreen. Sun damage is the single most important cause of premature aging. Last, if you have a tendency to engage in skin-damaging habits like smoking, excessive drinking, and tanning booths, please try to reduce or eliminate these habits altogether.

Remember, you want your skin to reflect and shine the beauty that we know you already are on the inside. Make all those years of wisdom and experience show on the outside as well.